Krustev L P, Dronzin R T, Dontchev N C, Borov B I, Kamenova B B, Beshevlieva M S
Gegenbaurs Morphol Jahrb. 1982;128(2):176-87.
White male Wistar rats were treated with Aflatoxin B1 for 2 months while on standard pellet food ad libitum or 80% undernutrition. Although each animal received 400 micrograms of AFB1 no cancer in the liver or elsewhere developed. Histologically the findings in the groups treated with the mycotoxin were the well known until now. Undernutrition led to atrophic and degenerative changes in the liver. Electronmicroscopically there were found marked changes in the nucleus, with microsegregation of the nucleolus; diminution and disorganization of endoplasmic reticulum and mitochondria; changes in the lysosomes, abundance of microbodies etc. with difference according to the intoxication, nutrition, or both of them. However, the combination of the 2 etiologic factors did not lead to a simple summation of the deleterious effect. At the same time, we do not have the right to claim a real "anticarcinogenic" action of undernutrition.
将雄性Wistar大白鼠置于标准颗粒饲料充足供应或80%营养不足的条件下，用黄曲霉毒素B1处理2个月。尽管每只动物都接受了400微克的黄曲霉毒素B1，但肝脏或其他部位均未发生癌变。从组织学上看，用霉菌毒素处理的组中的发现到目前为止都是众所周知的。营养不足导致肝脏出现萎缩和退行性变化。在电子显微镜下，发现细胞核有明显变化，核仁微分离；内质网和线粒体减少且紊乱；溶酶体变化，微体丰富等，根据中毒、营养或两者情况而有所不同。然而，这两种病因因素的组合并没有导致有害效应的简单叠加。同时，我们无权声称营养不足具有真正的“抗癌”作用。
