Jewkes J, Larson H E, Price A B, Sanderson P J, Davies H A
Gut. 1981 May;22(5):388-92. doi: 10.1136/gut.22.5.388.
We have studied 73 adults with acute diarrhoea and identified a micro-organism or toxin likely to be the cause in 58%. In addition to routinely cultured bacteria, Campylobacter coli/jejuni and Clostridium difficile were important pathogens in the community. Patients who developed diarrhoea after antibiotic use had a distinctive clinical syndrome and comprised the third largest group of cases. Clinical, epidemiological, and histological features in an additional group with negative cultures and no antibiotic history suggest that an additional bacterial pathogen remains to be identified as a cause of acute diarrhoea in adults.
我们研究了73名患有急性腹泻的成年人,发现58%的病例中可能存在致病微生物或毒素。除了常规培养的细菌外,空肠弯曲菌/结肠弯曲菌和艰难梭菌是社区中的重要病原体。使用抗生素后出现腹泻的患者具有独特的临床综合征,是第三大病例组。另一组培养结果为阴性且无抗生素使用史的患者的临床、流行病学和组织学特征表明,仍有待确定另一种细菌病原体作为成人急性腹泻的病因。