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三羟基二十碳三烯酸作为花生四烯酸与洗涤过的血小板孵育产物的鉴定。

The identification of trihydroxyeicosatrienoic acids as products from the incubation of arachidonic acid with washed blood platelets.

作者信息

Jones R L, Kerry P J, Poyser N L, Walker I C, Wilson N H

出版信息

Prostaglandins. 1978 Oct;16(4):583-9. doi: 10.1016/0090-6980(78)90188-0.

DOI:10.1016/0090-6980(78)90188-0
PMID:725088
Abstract

Arachidonic acid is converted by washed platelets from man, horse and dog into a mixture of 8,9,12-trihydroxyeicosa-5,10,14-trienoic acid and 8,11,12-trihydroxyeicosa-5,9,14-trienoic acid (termed 8,9,12-THETA and 8,11,12-THETA respectively and THETA collectively). Gas chromatographic--mass spectrometric evidence of structure is discussed.

摘要

来自人、马和狗的洗涤血小板可将花生四烯酸转化为8,9,12-三羟基二十碳-5,10,14-三烯酸和8,11,12-三羟基二十碳-5,9,14-三烯酸的混合物（分别称为8,9,12-THETA和8,11,12-THETA，统称为THETA）。讨论了结构的气相色谱-质谱证据。

相似文献

1
The identification of trihydroxyeicosatrienoic acids as products from the incubation of arachidonic acid with washed blood platelets.三羟基二十碳三烯酸作为花生四烯酸与洗涤过的血小板孵育产物的鉴定。
Prostaglandins. 1978 Oct;16(4):583-9. doi: 10.1016/0090-6980(78)90188-0.
2
The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets.环氧羟基酸作为花生四烯酸与洗涤过的血小板孵育产物的鉴定。
Prostaglandins. 1979 Aug;18(2):173-8. doi: 10.1016/0090-6980(79)90102-3.
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An epoxy-hydroxy product from arachidonate.一种源自花生四烯酸的环氧 - 羟基产物。
Adv Prostaglandin Thromboxane Res. 1980;6:107-9.
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Open tubular glass capillary gas chromatography for separating eicosanoids.
Methods Enzymol. 1982;86:612-31. doi: 10.1016/0076-6879(82)86233-2.
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Isolation of a new lipoxygenase metabolite of arachidonic acid, 8. 11, 12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets.从人血小板中分离出一种新的花生四烯酸脂氧合酶代谢产物，8,11,12-三羟基-5,9,14-二十碳三烯酸。
Prostaglandins. 1979 Jan;17(1):9-18. doi: 10.1016/0090-6980(79)90071-6.
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Evidence for a novel pathway of leukotriene formation in human platelets.
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[Effects of anisodamine on the metabolism of arachidonic acid by washed rat platelets].
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Electron capture gas chromatographic detection of thromboxane B2.血栓素B2的电子捕获气相色谱检测
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The effect of hydralazine on arachidonic acid metabolism in isolated, washed human platelets.肼苯哒嗪对分离、洗涤后的人血小板中花生四烯酸代谢的影响。
Res Commun Chem Pathol Pharmacol. 1980 Apr;28(1):43-52.
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Measurement of arachidonic acid release from human polymorphonuclear neutrophils and platelets: comparison between gas chromatographic and radiometric assays.人多形核中性粒细胞和血小板中花生四烯酸释放量的测定：气相色谱法和放射测定法的比较
Anal Biochem. 1991 Jan;192(1):173-80. doi: 10.1016/0003-2697(91)90203-6.

引用本文的文献

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Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.
Lipids. 1995 Feb;30(2):107-14. doi: 10.1007/BF02538262.
2
The prostanoids in hemostasis and thrombosis: a review.前列腺素类物质在止血和血栓形成中的作用：综述
Am J Pathol. 1980 Jun;99(3):743-804.
3
Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets.还原型谷胱甘肽对大鼠血小板中12-脂氧合酶途径的影响。
Biochem J. 1982 Mar 15;202(3):771-6. doi: 10.1042/bj2020771.
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Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.通过脂氧合酶和对抗炎药敏感的12L-氢过氧-5,8,10,14-二十碳四烯酸过氧化物酶进行的花生四烯酸代谢。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):308-12. doi: 10.1073/pnas.77.1.308.
5
Monohydroxylated fatty acid substrate specificity of human leukocyte 5-lipoxygenase and omega-hydroxylase.人白细胞5-脂氧合酶和ω-羟化酶的单羟基化脂肪酸底物特异性
Biochem J. 1988 Dec 15;256(3):879-83. doi: 10.1042/bj2560879.
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Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils.肝氧素A3可诱导人中性粒细胞胞质钙、细胞内pH值及膜电位发生变化。
Biochem J. 1990 Feb 15;266(1):63-8. doi: 10.1042/bj2660063.