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环氧羟基酸作为花生四烯酸与洗涤过的血小板孵育产物的鉴定。

The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets.

作者信息

Walker I C, Jones R L, Wilson N H

出版信息

Prostaglandins. 1979 Aug;18(2):173-8. doi: 10.1016/0090-6980(79)90102-3.

DOI:10.1016/0090-6980(79)90102-3
PMID:523677
Abstract

An epoxy-hydroxy compound, 10-hydroxy-11,12-epoxy-eicosa-5,8,14-trienoic acid, has been identified as a product on incubation of arachidonic acid with washed blood platelets from human, horse, cat, dog and rabbit. Gas chromatographic - mass spectrometric (GC-MS) evidence of structure is discussed.

摘要

一种环氧羟基化合物，10-羟基-11,12-环氧-二十碳-5,8,14-三烯酸，已被鉴定为花生四烯酸与人、马、猫、狗和兔子的洗涤血小板孵育后的产物。文中讨论了其结构的气相色谱-质谱（GC-MS）证据。

相似文献

1
The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets.环氧羟基酸作为花生四烯酸与洗涤过的血小板孵育产物的鉴定。
Prostaglandins. 1979 Aug;18(2):173-8. doi: 10.1016/0090-6980(79)90102-3.
2
An epoxy-hydroxy product from arachidonate.一种源自花生四烯酸的环氧 - 羟基产物。
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Human platelet PGE1 and dihomogammalinolenic acid. Comparison to PGE2 and arachidonic acid.人血小板中的前列腺素E1和二高-γ-亚麻酸。与前列腺素E2和花生四烯酸的比较。
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Metabolism of 8,11,14-eicosatrienoic acid in human platelets.
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Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma.
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Isolation of a new lipoxygenase metabolite of arachidonic acid, 8. 11, 12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets.从人血小板中分离出一种新的花生四烯酸脂氧合酶代谢产物，8,11,12-三羟基-5,9,14-二十碳三烯酸。
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Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.兔多形核白细胞对花生四烯酸和高γ-亚麻酸的转化。新型脂氧合酶产生的单羟基酸。
J Biol Chem. 1976 Dec 25;251(24):7816-20.
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Physiological relevance of the formation of 15-hydroxy derivative from dihomogammalinolenic acid in human platelets.人血小板中由二高-γ-亚麻酸形成15-羟基衍生物的生理相关性。
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Profiling of arachidonic acid metabolites in rabbit platelets by radio gas chromatography.用放射性气相色谱法分析兔血小板中花生四烯酸代谢物
Lipids. 1993 Apr;28(4):361-4. doi: 10.1007/BF02536324.

引用本文的文献

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Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.细胞色素P-450介导的花生四烯酸氧化生成羟基二十碳四烯酸。
Proc Natl Acad Sci U S A. 1982 Feb;79(3):767-70. doi: 10.1073/pnas.79.3.767.
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7
Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-icosatrienoic acid in Aplysia: a possible second messenger in neurons.海兔中8-羟基-11,12-环氧-5,9,14-二十碳三烯酸的形成与作用：神经元中一种可能的第二信使
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