前列腺素F2α（PGF2α）诱导的豚鼠离体胃纵肌收缩及钙运动

Prostaglandin F2alpha (PGF2alpha)-induced contraction and calcium movement in longitudinal muscle of guinea-pig isolated stomach.

作者信息

Ishizawa M, Miyazaki E

出版信息

Prostaglandins. 1978 Oct;16(4):591-7. doi: 10.1016/0090-6980(78)90189-2.

Abstract

Calcium movement and contractile responses to high K+ concentration and PGF2alpha were investigated in guinea-pig stimach longitudinal muscle. High K+ concentration (30 mM) and PGF2alpha (10(-7) M) produced similar contractions of guinea-pig stomach longitudinal muscle. The 'Ca-antagonist', verapamil (10(-5)-10(-4) M), prevented high K-induced contraction, but did not greatly reduce contractions to PGF2alpha. 45Ca uptake was increased by high K(30 mM) or PGF2alpha(10(-7) M). These increases in 45Ca uptake were greatly reduced with 10(-4) M verapamil. The results suggest that high K-induced contraction may depend on an increase in Ca influx. PGF2alpha-induced contraction may depend on both an increase in Ca influx and on an intracellular release of Ca.

摘要

在豚鼠胃纵肌中研究了钙的移动以及对高钾浓度和前列腺素F2α的收缩反应。高钾浓度（30 mM）和前列腺素F2α（10⁻⁷ M）可引起豚鼠胃纵肌产生相似的收缩。“钙拮抗剂”维拉帕米（10⁻⁵ - 10⁻⁴ M）可阻止高钾诱导的收缩，但对前列腺素F2α引起的收缩没有显著降低作用。高钾（30 mM）或前列腺素F2α（10⁻⁷ M）可增加⁴⁵Ca的摄取。用10⁻⁴ M维拉帕米可使这些⁴⁵Ca摄取的增加显著减少。结果表明，高钾诱导的收缩可能依赖于钙内流的增加。前列腺素F2α诱导的收缩可能既依赖于钙内流的增加，也依赖于细胞内钙的释放。