Traube M, Lange R C, McAllister R G, McCallum R W
Dig Dis Sci. 1985 Aug;30(8):710-2. doi: 10.1007/BF01320483.
We studied the effects of the calcium-channel blocker, nifedipine, on solid and liquid phases of gastric emptying in 10 healthy male volunteers. Each subject underwent a dual-isotope radionuclide gastric emptying determination with and without the preadministration of nifedipine, 30 mg orally, given 20 min prior to ingestion of the test meal over 10 min, following which the subject lay supine under the gamma-counter for 2 hr. Blood samples for measurement of plasma nifedipine concentration were obtained at the time of drug administration and every 30 min throughout the gastric emptying determination. There was a threefold variation in the areas under the plasma nifedipine concentration vs time curve (AUC) obtained in these 10 subjects. Percent gastric retention of either the liquid (water) or the solid (chicken liver) marker was not significantly different after 30 mg oral nifedipine, as compared to the nontreatment day. We concluded that plasma nifedipine concentrations previously reported to be associated with significant esophageal motility effects in humans were not associated with effects on gastric emptying of either liquids or solids.
我们研究了钙通道阻滞剂硝苯地平对10名健康男性志愿者胃排空固相和液相的影响。每位受试者在摄入试验餐（10分钟内）前20分钟口服30毫克硝苯地平或不服用硝苯地平的情况下，接受双同位素放射性核素胃排空测定，之后受试者在γ计数器下仰卧2小时。在给药时以及整个胃排空测定过程中每30分钟采集一次血样，用于测定血浆硝苯地平浓度。在这10名受试者中，血浆硝苯地平浓度-时间曲线下面积（AUC）存在三倍的差异。与未治疗日相比，口服30毫克硝苯地平后，液体（水）或固体（鸡肝）标志物的胃潴留百分比没有显著差异。我们得出结论，先前报道的与人类食管动力显著影响相关的血浆硝苯地平浓度与对液体或固体胃排空的影响无关。
