“循环纤维蛋白单体”的临床意义
Clinical significance of "circulating fibrin monomers'.
作者信息
Haselager E M, Vreeken J
出版信息
J Clin Pathol. 1981 May;34(5):468-72. doi: 10.1136/jcp.34.5.468.
During the decade 1970-9 we investigated circulating fibrin monomers in 3293 patients. Fibrinaemia was determined by means of the ethanol gelation test (EGT). This was positive in 149 patients (4.5%) and was highly correlated with fibrogenal fibrin products. In many diseases the test was only transiently positive (1 or 2 days). However in patients with circulating fibrin monomers, demonstrable for more than 5 days (chronic fibrinaemia) malignant disease was associated in 63%. Chronic fibrinaemia occasionally preceded overt malignancy by a long period. Overall, only 10.8% of patients with malignant disease showed chronic fibrinaemia. The clinical symptoms most often associated with chronic fibrinaemia were those of venous thrombosis (42.8%) and abnormal bleeding (10.7%). Thromboembolism in the absence of malignant disease only occasionally showed short-term positive EGT and chronic fibrinaemia was never seen. Almost half (46.5%) of patients with chronic fibrinaemia had neither thromboembolic disease nor a haemorrhagic diathesis.
在1970年至1979年这十年间，我们对3293例患者的循环纤维蛋白单体进行了研究。通过乙醇凝胶试验（EGT）测定纤维蛋白血症。149例患者（4.5%）呈阳性，且与纤维蛋白原性纤维蛋白产物高度相关。在许多疾病中，该试验仅短暂呈阳性（1或2天）。然而，在循环纤维蛋白单体可检测超过5天（慢性纤维蛋白血症）的患者中，63%患有恶性疾病。慢性纤维蛋白血症偶尔在明显的恶性肿瘤出现之前很长一段时间就已存在。总体而言，只有10.8%的恶性疾病患者表现出慢性纤维蛋白血症。与慢性纤维蛋白血症最常相关的临床症状是静脉血栓形成（42.8%）和异常出血（10.7%）。在无恶性疾病的情况下，血栓栓塞仅偶尔表现出短期EGT阳性，从未见过慢性纤维蛋白血症。几乎一半（46.5%）的慢性纤维蛋白血症患者既没有血栓栓塞性疾病也没有出血素质。
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