Smith H W, Tucker J F, Lovell M
J Hyg (Lond). 1981 Aug;87(1):71-81. doi: 10.1017/s0022172400069254.
Of 22 strains of Salmonella gallinarum isolated from recent outbreaks of infection in poultry in Greece (15). Amman (3), Kenya (2), Lebanon (1) and Yemen (1), 20 were more resistant to furazolidone in vitro than 6 strains that had been isolated in the U.K. in the 1950s; the minimum inhibitory concentration of furazolidone was approximately 0.3 microgram/ml for the sensitive strains and 1.3 or 2.5 microgram/ml for the more resistant strains. Furazolidone given continuously in the food did not control experimental infections in chickens caused by most of the strains that had been classed as more resistant by the in vitro tests. Chloramphenicol, trimethoprim and sulphadiazine or mixtures of the latter two were the best antibiotics for treating these infections, but they were less satisfactory than furazolidone for treating infections caused by the furazolidone-sensitive strains. As a group, the furazolidone-resistant strains and furazolidone-resistant mutants of one of the sensitive strains were less virulent for chickens than the sensitive strains.
从希腊（15株）、安曼（3株）、肯尼亚（2株）、黎巴嫩（1株）和也门（1株）近期家禽感染疫情中分离出的22株鸡沙门氏菌中，有20株在体外对呋喃唑酮的耐药性高于20世纪50年代在英国分离出的6株；呋喃唑酮对敏感菌株的最低抑菌浓度约为0.3微克/毫升，对耐药性更强的菌株为1.3或2.5微克/毫升。在食物中持续添加呋喃唑酮并不能控制由大多数经体外试验归类为耐药性更强的菌株引起的鸡实验性感染。氯霉素、甲氧苄啶和磺胺嘧啶或后两者的混合物是治疗这些感染的最佳抗生素，但在治疗由呋喃唑酮敏感菌株引起的感染方面，它们不如呋喃唑酮令人满意。总体而言，耐药性菌株以及其中一株敏感菌株的呋喃唑酮耐药突变体对鸡的毒性低于敏感菌株。
