苯乙烯环氧化物中间体作为淋巴细胞功能的一种可能刺激物。

Styrene epoxide intermediate as a possible stimulant of lymphocytic function.

作者信息

Sharma R P, Smith F A, Gehring P J

出版信息

J Immunopharmacol. 1981;3(1):67-78. doi: 10.3109/08923978109026419.

Abstract

Mice treated with styrene showed an increased lymphocyte transformation in splenic cell cultures. The effects were observed both on spontaneous transformation and phytomitogen induced blast formation. Addition of styrene oxide directly to splenic cultures, but not of styrene, increased blast formation at low concentrations but was cytotoxic at high concentrations. In this test system styrene exhibited a generalized immunostimulation. In vitro data suggest that this effect of styrene is mediated possibly through its conversion to styrene oxide, its transient metabolic intermediate.

摘要

用苯乙烯处理的小鼠在脾细胞培养物中显示出淋巴细胞转化率增加。在自发转化和植物血凝素诱导的胚细胞形成方面均观察到了这种效应。将环氧苯乙烷直接添加到脾细胞培养物中，而非苯乙烯，在低浓度时会增加胚细胞形成，但在高浓度时具有细胞毒性。在该测试系统中，苯乙烯表现出全身性免疫刺激作用。体外数据表明，苯乙烯的这种作用可能是通过其转化为环氧苯乙烷（其短暂的代谢中间体）介导的。