苯乙烯和环氧苯乙烷可诱导姐妹染色单体交换，并在人类淋巴细胞培养物中发生代谢。
Styrene and styrene oxide induce SCEs and are metabolised in human lymphocyte cultures.
作者信息
Norppa H, Sorsa M, Pfäffli P, Vainio H
出版信息
Carcinogenesis. 1980 Apr;1(4):357-61. doi: 10.1093/carcin/1.4.357.
PMID:7273276
Abstract
Both styrene and its presumed active metabolite styrene oxide show dose response as potent inducers of sister chromatid exchanges (SCEs) in human lymphocyte cultures. The SCE inducing and clastogenic capacity of styrene in lymphocytes in vitro can be explained by gas chromatographically measurable increase of styrene oxide in styrene treated cultures.
摘要
苯乙烯及其假定的活性代谢物氧化苯乙烯在人类淋巴细胞培养中，作为姐妹染色单体交换（SCEs）的有效诱导剂均呈现剂量反应。苯乙烯在体外淋巴细胞中的SCE诱导和致断裂能力，可以通过气相色谱法测定经苯乙烯处理的培养物中氧化苯乙烯的增加来解释。
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