在含有Fv-2rr和Fv-2ss骨髓的骨髓嵌合体中对Friend病毒刺激的红细胞生成的抗性表达。
Expression of resistance to Friend virus-stimulated erythropoiesis in bone marrow chimeras containing Fv-2rr and Fv-2ss bone marrow.
作者信息
Silver J, Teich N
出版信息
J Exp Med. 1981 Jul 1;154(1):126-37. doi: 10.1084/jem.154.1.126.
Abstract
Bone marrow chimeras were formed containing mixtures of DBA/2 (Fv-2ss, Hbbdd) and B10.D2 (Fv-2rr, Hbbss) bone marrow. When these mice were infected with the polycythemia-inducing strain of Friend virus, erythropoiesis was stimulated, but the proportion of B10.D2 hemoglobin fell rapidly and newly synthesized hemoglobin was essentially all of the DBA/2 type. The treatment of infected polycythemic chimeras with phenylhydrazine lowered the hematocrit and restored the synthesis of B10.D2 hemoglobin. These results imply that B10.D2 erythroid precursors are intrinsically resistant to Friend virus-stimulated erythropoiesis. The experiments also suggest that virus-stimulated erythropoiesis is not mediated by a factor or cell-cell interactions, unless such factors or interactions do not act across strain barriers.
摘要
构建了含有DBA/2（Fv - 2ss，Hbbdd）和B10.D2（Fv - 2rr，Hbbss）骨髓混合物的骨髓嵌合体。当这些小鼠感染多嗜性贫血诱导型Friend病毒时，红细胞生成受到刺激，但B10.D2血红蛋白的比例迅速下降，新合成的血红蛋白基本上全是DBA/2型。用苯肼处理感染多嗜性贫血的嵌合体可降低血细胞比容并恢复B10.D2血红蛋白的合成。这些结果表明，B10.D2红系前体细胞对Friend病毒刺激的红细胞生成具有内在抗性。这些实验还表明，病毒刺激的红细胞生成不是由一种因子或细胞间相互作用介导的，除非这种因子或相互作用不能跨越品系障碍发挥作用。
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Expression of resistance to Friend virus-stimulated erythropoiesis in bone marrow chimeras containing Fv-2rr and Fv-2ss bone marrow.在含有Fv-2rr和Fv-2ss骨髓的骨髓嵌合体中对Friend病毒刺激的红细胞生成的抗性表达。
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Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.具有白血病特征的疾病在成年瑞士小鼠中的无细胞传播。
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Replication of spleen focus-forming Friend virus in fibroblasts from C57BL mice that are genetically resistant to spleen focus formation.对脾灶形成具有遗传抗性的C57BL小鼠成纤维细胞中脾灶形成性Friend病毒的复制
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