Recovery of brain energy metabolism following a period of combined hypoxia and hypotension.
作者信息
Proctor H J, Wood J J
出版信息
Arch Int Physiol Biochim. 1977 Aug;85(3):479-85. doi: 10.3109/13813457709069865.
PMID:72525
Abstract
Rats were "stressed" by a 30-min period of hypoxia (FIO2 = 7.5%) and hypotension (x arterial pressure = 30 mm Hg), and then "resusciated" by restoring FIO2 = 30% and reinfusing shed blood to restore arterial pressure toward baseline values. Concentrations of brain phosphocreatine, ATP and lactate were measured after "stress" and 20, 60, and 120 min after "resuscitation". A biphasic response was noted in which ATP was initially restored to baseline values by "resuscitation", and then progressively decreased. Physiologic mechanisms to explain the observed data are presented.
摘要
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