牛肠系膜淋巴管中自发性收缩的神经调节
Nervous modulation of spontaneous contractions in bovine mesenteric lymphatics.
作者信息
McHale N G, Roddie I C, Thornbury K D
出版信息
J Physiol. 1980 Dec;309:461-72. doi: 10.1113/jphysiol.1980.sp013520.
Abstract
- Spontaneous isometric contractions were measured in 2 cm segments of bovine mesenteric lymphatics. 2. Field stimulation at 0.25, 1 anf 4 Hz increased the frequency of contraction. 3. Tetrodotoxin 3 x 10(-6) M blocked the response to electrical stimulation. 4. Phenoxybenzamine 3 x 10(-7) M converted the excitatory effect of stimulation to an inhibitory one. 5. Propranolol 3 x 10(-7) M potentiated the excitatory response to stimulation at 1 and 4 Hz. 6. Field stimulation was without effect in the presence of propranolol and phenoxybenzamine together. 7. Cocaine potentiated the response to stimulation at 0.25 and 1 Hz. 8. Atropine 3 x 10(-7) M failed to block the excitatory effect. 9. Field stimulation at 0.5 and 1 Hz increased the frequency of spontaneous contractions and propulsion of fluid by 8 cm cannulated segments of lymphatic. 10. The results suggest that bovine lymphatic vessels have a noradrenergic innervation which is capable of controlling lymph flow.
摘要
- 在牛肠系膜淋巴管的2厘米节段中测量自发等长收缩。2. 0.25、1和4赫兹的场刺激增加了收缩频率。3. 3×10⁻⁶ M的河豚毒素阻断了对电刺激的反应。4. 3×10⁻⁷ M的酚苄明将刺激的兴奋作用转化为抑制作用。5. 3×10⁻⁷ M的普萘洛尔增强了对1和4赫兹刺激的兴奋反应。6. 在普萘洛尔和酚苄明同时存在的情况下，场刺激无效。7. 可卡因增强了对0.25和1赫兹刺激的反应。8. 3×10⁻⁷ M的阿托品未能阻断兴奋作用。9. 0.5和1赫兹的场刺激增加了淋巴管8厘米插管节段的自发收缩频率和液体推进。10. 结果表明，牛淋巴管具有去甲肾上腺素能神经支配，能够控制淋巴流动。
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