Thiermann A B
J Wildl Dis. 1981 Jan;17(1):39-43. doi: 10.7589/0090-3558-17.1.39.
Laboratory raised wild Norway rat males (Rattus norvegicus) were injected with leptospires of two serovars: icterohaemorrhagiae and grippotyphosa. The development of a carrier state was monitored serologically, culturally and histologically. Rats infected with icterohaemorrhagiae developed rapidly into a chronic carrier state and shed leptospires in the urine for the duration of the experiment (220 days). At the time of necropsy, histopathologic studies showed evidence of leptospiral infections in the lumen of proximal convoluted tubules of some kidneys. Rats infected with grippotyphosa shed organisms for 40 days after inoculation; thereafter, they apparently cleared the infection. No organisms were detected histologically nor by culture at the end of the experiment (220 days). There appears to be a specific host-parasite relationship in the Norway rat towards becoming chronic carriers when infected with serotype icterohaemorrhagiae but not with grippotyphosa.
在实验室饲养的野生雄性挪威大鼠（褐家鼠）被注射了两种血清型的钩端螺旋体：黄疸出血型和犬型。通过血清学、培养和组织学方法监测携带状态的发展。感染黄疸出血型的大鼠迅速发展为慢性携带状态，并在实验期间（220天）尿液中排出钩端螺旋体。尸检时，组织病理学研究显示部分肾脏近端曲管腔内有钩端螺旋体感染的迹象。感染犬型的大鼠在接种后40天排出病原体；此后，它们显然清除了感染。在实验结束时（220天），组织学检查和培养均未检测到病原体。挪威大鼠在感染黄疸出血型血清型而非犬型血清型时，似乎存在一种特定的宿主 - 寄生虫关系，使其成为慢性携带者。
