头孢菌素I的药代动力学（作者译）
[Pharmacokinetics of cephaloridine (author's transl)].
作者信息
Imoto T
出版信息
Jpn J Antibiot. 1981 Feb;34(2):180-7.
I studied on absorption and excretion of cephaloridine. Cephaloridine was administered intravenously to 5 healthy volunteers weighing 65 kg to 83 kg, and the blood levels were measured. A cross over test subjecting 2 grams intravenous drip infused for 1 hour against the same dose for 2 hours were performed after 1 week interval. The disposition of cephaloridine was estimated by applying one-compartment model which was scaled from YOKOKAWA & HULET PACKARD'S disc top computer. Pharmacokinetic parameters are as followings: 1 hour d.i.v.: Kel 1.410 (hr-1), Vd 9.629(L), T 1/2 30.290 (min.) 2 hours d.i.v.: Kel 0.876 (hr-1), Vd 21.106(L), T 1/2 49.372 (min.).
我研究了头孢菌素的吸收与排泄。对5名体重在65公斤至83公斤之间的健康志愿者静脉注射头孢菌素，并测定血药浓度。采用交叉试验，间隔1周后，分别以相同剂量静脉滴注1小时（2克）和静脉滴注2小时（2克）。运用从横河与惠普台式计算机扩展而来的一室模型来估算头孢菌素的处置情况。药代动力学参数如下：静脉滴注1小时：消除速率常数（Kel）1.410（小时⁻¹），分布容积（Vd）9.629（升），半衰期（T 1/2）30.290（分钟）；静脉滴注2小时：消除速率常数（Kel）0.876（小时⁻¹），分布容积（Vd）21.106（升），半衰期（T 1/2）49.372（分钟）。
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