Kawashima M, Torisu T
Jpn J Antibiot. 1977 Apr;30(4):278-80.
Cephaloridine (CER) concentration in the bone marrow of tibia was examined 1, 2, and 3 hours after intramuscular injection of 1 g. CER concentration in the bone marrow of tibia 1 hour after injection was 26.0+/-8.927 microng/ml. Ratio to serum was 78.5%. CER concentration in the bone marrow of tibia 2 hours after injection was 20.6+/-5.003 microng/ml. Ratio to serum was 87.3%. CER concentration of bone marrow of tibia 3 hours after injection was 14.8+/-4.79 microng/ml. Ratio to serum was 91.9%. Difference of concentration between in bone marrow and serum was not statistically significant. Penetration capacity of CER into the bone marrow of tibia was excellent.
肌肉注射1克头孢菌素后1、2和3小时，检测胫骨骨髓中头孢菌素（CER）的浓度。注射后1小时，胫骨骨髓中CER浓度为26.0±8.927微克/毫升。与血清的比值为78.5%。注射后2小时，胫骨骨髓中CER浓度为20.6±5.003微克/毫升。与血清的比值为87.3%。注射后3小时，胫骨骨髓中CER浓度为14.8±4.79微克/毫升。与血清的比值为91.9%。骨髓和血清中的浓度差异无统计学意义。CER进入胫骨骨髓的穿透能力极佳。
