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A convective mass transfer model for determining intestinal wall permeabilities: laminar flow in a circular tube.

作者信息

Elliott R L, Amidon G L, Lightfoot E N

出版信息

J Theor Biol. 1980 Dec 21;87(4):757-71. doi: 10.1016/0022-5193(80)90115-0.

DOI:10.1016/0022-5193(80)90115-0
PMID:7253676
Abstract
摘要

相似文献

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A convective mass transfer model for determining intestinal wall permeabilities: laminar flow in a circular tube.一种用于确定肠壁通透性的对流质量传递模型：圆管中的层流。
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Improving intestinal absorption of water-insoluble compounds: a membrane metabolism strategy.
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Analysis of models for determining intestinal wall permeabilities.用于确定肠壁通透性的模型分析
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A drug absorption model of the intestinal tract based on the two-dimensional laminar flow in a circular tube.一种基于圆管内二维层流的肠道药物吸收模型。
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[Absorption of aspirin by the jejunal mucosa of rats].[大鼠空肠黏膜对阿司匹林的吸收]
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[Mucus models for investigation of intestinal absorption mechanisms. 1. Validation and optimization of the model].[用于肠道吸收机制研究的黏液模型。1. 模型的验证与优化]
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Concentration profile in the intestinal tract and drug absorption model: two-dimensional laminar flow in a circular porous tube.肠道内的浓度分布与药物吸收模型：圆形多孔管中的二维层流。
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Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability.采用黏液-PVPA 体外模型模拟肠道区域性和禁食/进食状态：pH 值和模拟肠液对药物渗透性的影响。
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Application of the MechPeff model to predict passive effective intestinal permeability in the different regions of the rodent small intestine and colon.应用MechPeff模型预测啮齿动物小肠和结肠不同区域的被动有效肠道通透性。
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引用本文的文献

1
G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 12, 413-420, 1995--backstory of BCS.G.L. 阿米顿、H. 伦纳纳斯、V.P. 沙阿和J.R. 克里森。生物药剂学药物分类的理论基础：体外药物产品溶出度与体内生物利用度的相关性，《药物研究》12卷，413 - 420页，1995年——生物药剂学分类系统的背景故事
AAPS J. 2014 Sep;16(5):894-8. doi: 10.1208/s12248-014-9620-9. Epub 2014 Jun 25.
2
Analysis of a diffusion dryer for the respiratory delivery of poorly water soluble drugs.用于呼吸道递送难溶性药物的扩散干燥器分析
Pharm Res. 1999 Dec;16(12):1857-63. doi: 10.1023/a:1018903426344.
3
In vitro and in situ permeability of a 'second generation' hydroxypyridinone oral iron chelator: correlation with physico-chemical properties and oral activity.
一种“第二代”羟基吡啶酮口服铁螯合剂的体外和原位渗透性：与物理化学性质及口服活性的相关性
Pharm Res. 1999 Mar;16(3):434-40. doi: 10.1023/a:1018886005136.
4
Permeability and clearance views of drug absorption: a commentary.药物吸收的通透性和清除率观点：一篇评论
J Pharmacokinet Biopharm. 1995 Jun;23(3):333-43. doi: 10.1007/BF02354289.
5
We may not measure the correct intestinal wall permeability coefficient of drugs: alternative absorptive clearance concept.我们可能无法测量药物正确的肠壁渗透系数：替代性吸收清除概念。
J Pharmacokinet Biopharm. 1995 Jun;23(3):323-31. doi: 10.1007/BF02354288.
6
Closed rat jejunal segment in situ: role of pre-epithelial diffusion resistance (unstirred layer) in the absorption process and model analysis.原位闭合大鼠空肠段：上皮前扩散阻力（静止层）在吸收过程中的作用及模型分析
Naunyn Schmiedebergs Arch Pharmacol. 1987 Feb;335(2):204-15. doi: 10.1007/BF00177725.
7
Use of laminar flow and unstirred layer models to predict intestinal absorption in the rat.使用层流和未搅拌层模型预测大鼠肠道吸收情况。
J Clin Invest. 1988 May;81(5):1365-9. doi: 10.1172/JCI113464.
8
Estimate of volume/flow ratio of gastrointestinal (GI) fluids in humans using pharmacokinetic data.
Pharm Res. 1990 May;7(5):518-22. doi: 10.1023/a:1015825018361.
9
Mechanism of acyclovir uptake in rat jejunum.
Pharm Res. 1990 Mar;7(3):299-303. doi: 10.1023/a:1015890516119.
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Calculation of the aqueous diffusion layer resistance for absorption in a tube: application to intestinal membrane permeability determination.
Pharm Res. 1991 Mar;8(3):298-305. doi: 10.1023/a:1015829128646.