Garlepp M J, Kay P H, Dawkins R L, Bucknall R C, Kemp A
Muscle Nerve. 1981 Jul-Aug;4(4):282-8. doi: 10.1002/mus.880040404.
The heterogeneity of the specificities of anti-acetylcholine receptor (anti-AChR) antibodies of myasthenia gravis (MG) patients has been demonstrated by comparing reactions against a panel of xenogeneic AChR. For each patient there was a more or less unique cross-reactivity profile. Such heterogeneity emphasizes the need to use human AChR for the routine detection of anti-AChR. In vitro cross-reactivity was important in predicting the effect of anti-AChR after passive transfer to rats. Specificity may influence the outcome in human neonates receiving maternal anti-AChR via the placenta. In contrast to the extreme heterogeneity seen in spontaneous MG, the antibodies associated with D-penicillamine-induced MG were more homogeneous.
通过比较针对一组异种乙酰胆碱受体（AChR）的反应，已证明重症肌无力（MG）患者抗乙酰胆碱受体（抗AChR）抗体特异性的异质性。对于每位患者，都有或多或少独特的交叉反应谱。这种异质性强调了在抗AChR的常规检测中使用人AChR的必要性。体外交叉反应在预测抗AChR被动转移至大鼠后的效果方面很重要。特异性可能会影响通过胎盘接受母体抗AChR的人类新生儿的结局。与自发性MG中所见的极端异质性相反，与青霉胺诱导的MG相关的抗体更为均一。
