Anderson R A, Furby J E, Oswald C, Zaneveld L J
Neurobehav Toxicol Teratol. 1981 Summer;3(2):117-20.
Numerous studies have appeared in the literature which suggest that paternal alcohol consumption may have adverse effects on subsequent offspring. However, to date, no teratologic examination has been performed on fetuses conceived subsequent to paternal alcohol consumption. The present study has examined fetuses conceived by alcohol-treated male Swiss webster mice for gross anatomical congenital defects in an attempt to evaluate a possible mechanism for decreased viability of offspring sired by alcoholic males. Sexually mature males were maintained for 28 days on a total liquid nutriment diet in which alcohol (6.3%, v/v, U.S.P. ethanol) comprised 32% of the caloric content. Subsequently, the animals were mated with nulliparous females. On day 18 of gestation, the gravid females were sacrificed and the fetuses were examined for congenital defects. Only 14% of the matings which occurred 3--5 days after alcohol treatment resulted in pregnancy, as compared to a pregnancy rate of 100% for matings from pair-fed controls during the same period. Fetuses sired by alcohol-treated males during this time had reduced birth weights (0.85 +/- 0.04 g vs 0.92 +/- 0.11 g;p = 0.059) and crown-rump lengths (1.83 +/- 0.06 cm vs 1.99 +/- 0.11 cm;p less than 0.001) as compared to control fetuses. The frequency of congenital defects did not differ significantly between the experimental and control groups. No significant differences were noted between experimental and control progeny conceived more than 5 days after alcohol treatment. These results suggest that although some changes may be seen in progeny sired by alcohol treated males, the specific anomalies associated with the Fetal Alcohol Syndrome are most probably not due to paternal alcoholism.
文献中已出现大量研究表明，父亲饮酒可能会对其后代产生不良影响。然而，迄今为止，尚未对父亲饮酒后受孕的胎儿进行致畸学检查。本研究检查了经酒精处理的雄性瑞士韦伯斯特小鼠所孕育的胎儿，以观察其大体解剖结构上的先天性缺陷，试图评估酗酒雄性所育后代活力降低的可能机制。性成熟的雄性小鼠在全液体营养饮食中饲养28天，其中酒精（6.3%，v/v，美国药典级乙醇）占热量的32%。随后，将这些动物与未生育的雌性小鼠交配。在妊娠第18天，处死妊娠雌性小鼠并检查胎儿是否有先天性缺陷。与同期配对饲养对照组的交配受孕率100%相比，酒精处理后3 - 5天发生的交配中只有14%导致怀孕。在此期间，由酒精处理过的雄性小鼠所育胎儿的出生体重（0.85±0.04克对0.92±0.11克；p = 0.059）和顶臀长度（1.83±0.06厘米对1.99±0.11厘米；p＜0.001）均低于对照胎儿。实验组和对照组之间先天性缺陷的发生率没有显著差异。酒精处理后5天以上受孕的实验组和对照组后代之间未发现显著差异。这些结果表明，虽然在酒精处理过的雄性小鼠所育后代中可能会观察到一些变化，但与胎儿酒精综合征相关的特定异常很可能并非由父亲酗酒所致。
