Del Principe D, Boscherini B, Menichelli A, Giardini O, Mastracchio F, Malvaso M, Gabriotti M, Spadoni G L
Nouv Presse Med. 1981 May 30;10(24):2015-7.
Oxygen consumption in blood platelets of 14 pituitary dwarfs aged from 2 to 8 years was investigated before and after a 2 months' treatment with growth hormone (GH). No significant difference was found between dwarfs and control subjects in respect of basal platelet oxygen uptake (4.0 +/- 3.8 mmol O2/10(9) platelets/min in dwarfs as against 6.4 +/- 4.1 in controls), but the abrupt increase in oxygen consumption induced by thrombin was significantly reduced in dwarfs (4.3 +/- 4.1) as compared with controls (12.3 +/- 7.6; p less than 0.01). During GH treatment, however, the dwarfs' response to thrombin stimulation was similar to that of controls. Since dwarfs had normal platelet malonyldialdehyde production, it is likely that the mitochondrial component of thrombin-induced high oxygen consumption was deficient. These results suggest that blood platelets may contribute to the protective effect of GH deficiency against atherosclerosis.
对14名年龄在2至8岁的垂体性侏儒症患者的血小板耗氧量进行了研究，观察了生长激素（GH）治疗2个月前后的情况。在基础血小板氧摄取方面，侏儒症患者与对照受试者之间未发现显著差异（侏儒症患者为4.0±3.8 mmol O2/10⁹血小板/分钟，而对照受试者为6.4±4.1），但与对照受试者（12.3±7.6；p<0.01）相比，侏儒症患者中凝血酶诱导的耗氧量突然增加显著降低（4.3±4.1）。然而，在GH治疗期间，侏儒症患者对凝血酶刺激的反应与对照受试者相似。由于侏儒症患者血小板丙二醛生成正常，凝血酶诱导的高耗氧量的线粒体成分可能存在缺陷。这些结果表明，血小板可能有助于GH缺乏对动脉粥样硬化的保护作用。
