Dighiero G, Lesty C, Couty M C, Binet J L
Nouv Rev Fr Hematol (1978). 1980;22(4):383-90.
The modal volume of peripheral blood lymphocytes from 23 patients with chronic lymphoid leukemia (CLL) was measured by a Coulter ZBI linked to a channalyzer C 1000, varied from 140 to 262 mu3. A statistical correlation between the modal volume and anatomo-clinical forms of the disease was determined: a modal volume below 190 mu3 was statistically found among early forms while a volume over this threshold corresponded to advanced forms. Since Sipe et al. postulated that cell volume might be relayed to the cell kinetics, we attempted to determine the volume distribution law of lymphocytes from 12 CLL cases by applying the chi-square distance test. The best adjustment was observed with the two log-normal populations model, but this adjustment was acceptable for only five cases over twelve. The instability in the determination of the percentage of the second population made it impossible + relate it with the proliferative cell fraction. Moreover, this model did not provide more significant information than the single modal volume.
使用与通道分析仪C 1000相连的库尔特ZBI测量了23例慢性淋巴细胞白血病（CLL）患者外周血淋巴细胞的模态体积，其范围在140至262立方微米之间。确定了模态体积与疾病解剖临床形式之间的统计相关性：在疾病早期形式中，统计学上发现模态体积低于190立方微米，而超过此阈值的体积则对应于晚期形式。由于西佩等人推测细胞体积可能与细胞动力学有关，我们试图通过应用卡方距离检验来确定12例CLL病例淋巴细胞的体积分布规律。在双对数正态总体模型中观察到最佳拟合，但在12例病例中只有5例的这种拟合是可接受的。第二总体百分比测定的不稳定性使得无法将其与增殖细胞分数相关联。此外，该模型没有提供比单模态体积更有意义的信息。
