具有左手螺旋结构的寡核苷酸与溴化乙锭之间的相互作用。
Interactions between oligonucleotides having a left-handed helical structure and ethidium bromide.
作者信息
Uesugi S, Shida T, Miyamae A, Ikehara M
出版信息
Nucleic Acids Symp Ser. 1980(8):s147-50.
PMID:7255187
Abstract
Oligonucleotides containing a 8,2'-S-cycloadenosine(As), 8,2'-S-cycloinosine(Is), 6,2'-O-cyclouridine(Uo) and 6,2'-O-cyclocytidine(Co) residues, which have a glycosidic torsion angle(chi) of about 120 degrees, were synthesized. Among these oligomers, AspUo, AspIs and (pCo)4 + (pIs)4 formed a complex with ethidium bromide, which was assumed to be intercalated between the adjacent base-pairs of the left-handed double helix.
摘要
合成了含有8,2'-S-环腺苷（As）、8,2'-S-环肌苷（Is）、6,2'-O-环尿苷（Uo）和6,2'-O-环胞苷（Co）残基的寡核苷酸，这些残基的糖苷扭转角（χ）约为120度。在这些寡聚物中，AspUo、AspIs和（pCo）4 + （pIs）4与溴化乙锭形成复合物，推测该复合物插入左手双螺旋相邻碱基对之间。
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