Noel-Jorand M C, Schmidt D N, Devaux M A, Sarles H
Regul Pept. 1981 Jun;2(3):181-91. doi: 10.1016/0167-0115(81)90012-4.
Persisting modifications induced by repeated intravenous calcium infusion (acute hypercalcaemia) were investigated in 6 Thomas fistula dogs: 4 controls and 4 calcium-treated dogs, two of which were studied as controls. (a) The pancreatic response to graded doses of synthetic secretin (water and bicarbonate outputs) was significantly reduced in calcium-treated dogs when compared with controls. As both the D50 for secretin-induced response increased, and the maximal secretory response decreased, if may be concluded that calcium treatment decreased the sensitivity of duct cells to secretin and reduced their secretory capacity. (b) A similar dose-response relationship was observed between secretin and pancreatic calcium outputs in controls and calcium-treated dogs. The secretin induced pancreatic calcium secretion was independent of protein secretion and latter not being modified by secretin. Thus it may be assumed that the secretory fluid calcium originated form a protein independent pool and had a dose-dependent relationship to secretin. (c) These results help to illuminate the aetiology of chronic pancreatitis induced by acute hypercalcaemia and by hyperparathyroidism.
在6只托马斯瘘管犬中研究了反复静脉输注钙（急性高钙血症）引起的持续性改变：4只对照犬和4只接受钙治疗的犬，其中2只接受钙治疗的犬作为对照进行研究。（a）与对照犬相比，接受钙治疗的犬对不同剂量合成促胰液素的胰腺反应（水和碳酸氢盐分泌量）显著降低。由于促胰液素诱导反应的半数有效剂量（D50）增加，且最大分泌反应降低，因此可以得出结论，钙治疗降低了导管细胞对促胰液素的敏感性并降低了其分泌能力。（b）在对照犬和接受钙治疗的犬中，促胰液素与胰腺钙分泌量之间观察到类似的剂量反应关系。促胰液素诱导的胰腺钙分泌与蛋白质分泌无关，且蛋白质分泌不受促胰液素影响。因此可以推测，分泌液中的钙源自与蛋白质无关的池，且与促胰液素呈剂量依赖关系。（c）这些结果有助于阐明急性高钙血症和甲状旁腺功能亢进引起的慢性胰腺炎的病因。
