Wood R A, Moossa A R
Br J Surg. 1977 Oct;64(10):718-20. doi: 10.1002/bjs.1800641009.
An unselected series of 136 patients suspected of having a major intra-abdominal pathological condition had blood drawn and stored as serum. A definitive histological diagnosis was made in all cases, usually by laparotomy. The serum was analysed with coded samples for carcino-embryonic antigen, alpha-fetoprotein and pancreatic oncofetal antigen and all recorded levels above the upper limit of normal for that test were taken as a positive result. Results were analysed to give the predictive value of a positive test and a negative test for each antigen. A negative pancreatic oncofetal antigen test was found to be useful in excluding a diagnosis of pancreatic cancer.
对136例疑似患有严重腹腔内病理状况的患者进行了非选择性抽样，采集血液并储存为血清。所有病例均做出了明确的组织学诊断，通常是通过剖腹手术。对血清进行编码样本分析，检测癌胚抗原、甲胎蛋白和胰腺癌胚抗原，所有记录的高于该检测正常上限的水平均被视为阳性结果。对结果进行分析，以得出每种抗原阳性检测和阴性检测的预测价值。发现胰腺癌胚抗原阴性检测有助于排除胰腺癌的诊断。
