Hamazoe R, Yoshioka H, Ikeda Y, Shimizu N, Koga S
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Gastroenterol Jpn. 1987 Aug;22(4):503-8. doi: 10.1007/BF02773820.
An autopsy was performed of a patient who succumbed to pancreatic carcinoma and in whom an unusually high level of serum alpha-fetoprotein (AFP) (84,000 ng/ml) was obtained. An immunohistochemical approach, utilizing the peroxidase-antiperoxidase method, proved that AFP was confined within pancreatic carcinomatous cells of the primary lesion and liver metastases. No AFP-positive cells were ever observed in the hepatocytes adjacent to the metastatic lesions in the liver. It may be inferred that, in this particular case, the carcinomatous cells themselves synthesize AFP. The sites of production of AFP in AFP-positive pancreatic carcinoma were discussed in a review of the literature.
对一名死于胰腺癌且血清甲胎蛋白（AFP）水平异常高（84,000纳克/毫升）的患者进行了尸检。采用过氧化物酶-抗过氧化物酶方法的免疫组织化学方法证明，AFP局限于原发性病变和肝转移灶的胰腺癌细胞内。在肝脏转移灶附近的肝细胞中从未观察到AFP阳性细胞。可以推断，在这个特殊病例中，癌细胞自身合成AFP。通过文献综述讨论了AFP阳性胰腺癌中AFP的产生部位。
