Kallner A B, Hartmann D, Hornig D H
Am J Clin Nutr. 1981 Jul;34(7):1347-55. doi: 10.1093/ajcn/34.7.1347.
The time course of radioactivity in plasma and urine after oral administration of a single dose of (1-14 C) ascorbic acid has been followed in healthy male volunteers smoking more than 20 cigarettes per day. The investigation was carried out under steady state conditions with regard to ascorbic acid plasma levels at intakes of about 30 to 180 mg/day. Smokers had a higher metabolic turnover than that found for nonsmokers. It was concluded, as a consequence, that a daily intake of at least 140 mg is required for smokers to reach steady state concentrations and total body pools comparable to nonsmokers for whom a daily intake of about 100 mg was previously reported to be appropriate.
在每天吸烟超过20支的健康男性志愿者中，跟踪了口服单剂量（1-¹⁴C）抗坏血酸后血浆和尿液中放射性的时间进程。该研究是在稳态条件下进行的，抗坏血酸血浆水平的摄入量约为每天30至180毫克。吸烟者的代谢周转率高于非吸烟者。因此得出结论，吸烟者每天至少需要摄入140毫克才能达到与非吸烟者相当的稳态浓度和全身储备，此前报道非吸烟者每天摄入约100毫克是合适的。
