Manci E A, Balch C M, Murad T M, Soong S J
Am J Clin Pathol. 1981 Jun;75(6):810-5. doi: 10.1093/ajcp/75.6.810.
Thirty-two patients who had polypoid melanoma were identified in a registry of 552 melanoma patients. The tumor is regarded as a variant of nodular melanoma and is associated with an increased thickness, more frequent ulceration than the nodular variant of melanoma, younger patient age, and higher probability of occult metastasis. Polypoid melanomas were most frequently present on the trunk, and were also encountered in unusual sites, such as the mucosa of the nose, hard palate, and anorectal junction. In terms of survival, the patients with the polypoid nodular variant fared significantly worse than those with nonpolypoid nodular (P = 0.05) and those with superficial spreading (P = 0.003) melanomas. The five-year survival rate for polypoid variant was 42%, in contrast to 57% for the nonpolypoid nodular and 77% for the superficial spreading melanomas. The poor prognosis of patients who have polypoid melanoma is most likely due to its being the type of melanoma with the deepest penetration at the time of surgical excision.
在一个包含552例黑色素瘤患者的登记册中，确定了32例患有息肉样黑色素瘤的患者。该肿瘤被视为结节性黑色素瘤的一种变体，与厚度增加、溃疡比黑色素瘤的结节性变体更频繁、患者年龄较轻以及隐匿性转移的可能性较高有关。息肉样黑色素瘤最常出现在躯干上，也出现在不寻常的部位，如鼻黏膜、硬腭和肛管直肠交界处。在生存方面，息肉样结节性变体的患者预后明显比非息肉样结节性（P = 0.05）和浅表扩散性（P = 0.003）黑色素瘤的患者差。息肉样变体的五年生存率为42%，相比之下，非息肉样结节性为57%，浅表扩散性黑色素瘤为77%。患有息肉样黑色素瘤的患者预后不良很可能是因为它是手术切除时浸润最深的黑色素瘤类型。
