Rocke D A, Rubin J, Brock-Utne J G, Downing J W
Anaesth Intensive Care. 1981 May;9(2):119-23. doi: 10.1177/0310057X8100900203.
A technique of total intravenous anaesthesia using etomidate by bolus intravenous (IV) injection for induction and by continuous intravenous infusion for maintenance of anaesthesia, with supplementary intravenous fentanyl analgesia, is described. Muscle relaxation was provided by competitive neuromuscular blockade, allowing controlled ventilation of the lungs with oxygen-enriched air. Arterial blood pressure, heart rate and rhythm remained stable throughout the procedure. Few complications were encountered of which the most significant was a 13% incidence of nausea and/or vomiting. Pain on injection, abnormal muscular movements on induction, and post operative venous sequelae were uncommon. Patients were easily rousable shortly after termination of drug infusion. The technique proved acceptable to the patient, surgeon and experienced anaesthetist and, thereby, would appear to offer a reasonable alternative to the more conventional inhalational anaesthetic technique.
描述了一种全静脉麻醉技术，诱导采用依托咪酯静脉推注，维持麻醉采用静脉持续输注，并辅以静脉注射芬太尼镇痛。通过竞争性神经肌肉阻滞提供肌肉松弛，以便使用富氧空气进行肺的控制通气。整个手术过程中动脉血压、心率和心律保持稳定。遇到的并发症很少，其中最显著的是恶心和/或呕吐发生率为13%。注射时疼痛、诱导时异常肌肉运动以及术后静脉后遗症并不常见。药物输注结束后不久患者很容易被唤醒。该技术被患者、外科医生和经验丰富的麻醉师所接受，因此，似乎是更传统吸入麻醉技术的合理替代方案。
