Eiler H, Oden J, Schaub R, Sims M
Am J Vet Res. 1981 Feb;42(2):314-7.
Uterine and mammary pressure changes were simultaneously measured in lactating nonpregnant cows injected (IV) with different doses (0.1 to 32.0 mg) of prostaglandin F2 alpha (PGF2 alpha). The total work of the uterus increased up to 250% of base-line value as the dose of PGF2 alpha was increased. But, a dose-response relationship was not seen in the uterus. Partial refractoriness was developed in the uterus, and total refractoriness was developed in the mammary gland. Further challenge with oxytocin (30 U) elicited significant responses in both the uterus and the mammary gland. Because of the development of refractoriness and side effects, PGF2 alpha is not recommended as a drug to be used when mechanical evacuation (free of endocrine effect) of the uterus or mammary gland (or both) is indicated.
在给非妊娠泌乳奶牛静脉注射不同剂量（0.1至32.0毫克）的前列腺素F2α（PGF2α）时，同时测量子宫和乳腺的压力变化。随着PGF2α剂量的增加，子宫的总功增加至基线值的250%。但是，在子宫中未观察到剂量反应关系。子宫出现了部分不应性，乳腺出现了完全不应性。用催产素（30单位）进一步刺激后，子宫和乳腺均出现了显著反应。由于不应性的产生和副作用，当需要对子宫或乳腺（或两者）进行机械排空（无内分泌作用）时，不建议使用PGF2α作为药物。
