Allen P C, Kuttler K L, Amerault T E
Am J Vet Res. 1981 Feb;42(2):326-8.
In a comparative study of the clinical chemical changes during Anaplasma marginale infection, 16 intact mature cows were infected with either of 2 virulent isolates. Eight others were treated with a live A marginale vaccine (sheep-attenuated) and 7 were maintained as controls. Before and during patency, samples of blood from the cows were analyzed for total WBC, parasitemia, card test titer (CTT), total protein, albumin, and globulin fractions. In the cows inoculated with virulent isolates, albumin was significantly depressed throughout patency, whereas gamma-globulins and WBC were increased after peak parasitemia, as well as during recovery. The CTT was highest immediately after peak parasitemia. A significant increase was not observed in beta-globulin. Seven of the 16 infected cows died, but no consistent patterns of change in serum protein fractions or WBC could be associated with mortality. The 8 cows vaccinated with the attenuated isolate showed a significant mean decrease in albumin throughout patency, but no significant mean increase in alpha- or beta-globulin. A mean increase in gamma-globulin was observed only during the recovery period. The CTT increased gradually throughout patency, peaking during the recovery period. A significant mean increase over control in WBC count was observed only during rising parasitemia.
在一项关于边缘无形体感染期间临床化学变化的比较研究中，16头健康成熟奶牛感染了两种强毒株中的一种。另外8头奶牛接种了活的边缘无形体疫苗（绵羊减毒），7头作为对照。在显症期之前和期间，对奶牛的血液样本进行分析，检测总白细胞、寄生虫血症、卡片试验滴度（CTT）、总蛋白、白蛋白和球蛋白组分。在接种强毒株的奶牛中，白蛋白在整个显症期显著降低，而γ球蛋白和白细胞在寄生虫血症高峰期后以及恢复期间增加。CTT在寄生虫血症高峰期后立即最高。β球蛋白未观察到显著增加。16头感染奶牛中有7头死亡，但血清蛋白组分或白细胞的变化模式与死亡率没有一致性关联。接种减毒株的8头奶牛在整个显症期白蛋白显著平均降低，但α或β球蛋白没有显著平均增加。仅在恢复期观察到γ球蛋白平均增加。CTT在整个显症期逐渐增加，在恢复期达到峰值。仅在寄生虫血症上升期间观察到白细胞计数比对照有显著平均增加。
