Iakovleva E P, Kuznetsova O S, Tsyganov V A
Antibiotiki. 1981 May;26(5):327-32.
Experiments on isolation of active substances or biostimulators from the culture fluids of yeast-like fungi of Candida (C. tropicalis, strain 159) were performed. Addition of the biostimulators to the fermentation medium for cultivation of the levorin-producing actinomycete provided the same levels of the antibiotic synthesis as mixed cultivation of the actinomycete and C. tropicalis. The biostimulators were found to be thermostable and stable within a wide pH range (2.0--14.0). They are low-molecular compounds of the organic nature.
开展了从假丝酵母(热带假丝酵母,菌株159)的类酵母真菌培养液中分离活性物质或生物刺激剂的实验。将生物刺激剂添加到用于培养产左霉素放线菌的发酵培养基中,抗生素合成水平与放线菌和热带假丝酵母混合培养时相同。发现生物刺激剂具有热稳定性,且在较宽的pH范围(2.0 - 14.0)内稳定。它们是具有有机性质的低分子化合物。