Saligaut C, Moore N, Daoust M, Chretien P, Boismare F
Arch Int Pharmacodyn Ther. 1981 May;251(1):80-7.
In the present work we attempted to show whether a modification of the sensitivity of the dopaminergic receptors could act on the learning process in hypobaric hypoxia. Acute treatment with 1 mg/kg-1/day-1 pimozide increases the hypoxia-induced deleterious effect on a conditioned avoidance test whilst chronic administration of pimozide improves behavioral performances in hypoxic rats. Chronic treatment with apomorphine does not modify the learning both in normoxic and hypoxic rats in comparison with control rats, while acute treatment induces an anti-hypoxic protection and a fall in total responses (avoidance + escape). A pimozide-induced hypersensitivity (by chronic treatment) or a direct apomorphine-induced stimulation (by acute treatment) of post-synaptic dopaminergic receptors oppose the deleterious effects of hypobaric hypoxia.
在本研究中，我们试图探究多巴胺能受体敏感性的改变是否会对低压缺氧环境下的学习过程产生影响。每天以1 mg/kg的剂量急性给予匹莫齐特，会增强缺氧对条件性回避试验产生的有害作用，而长期给予匹莫齐特则可改善缺氧大鼠的行为表现。与对照大鼠相比，长期给予阿扑吗啡对常氧和缺氧大鼠的学习能力均无影响，而急性给予阿扑吗啡则可诱导产生抗缺氧保护作用，并使总反应次数（回避 + 逃避）减少。匹莫齐特长期给药诱导的超敏反应（通过慢性给药）或阿扑吗啡直接诱导的突触后多巴胺能受体刺激（通过急性给药）可对抗低压缺氧的有害影响。
