吡贝地尔对大鼠的抗缺氧保护作用。

Piribedil-induced anti-hypoxic protection in rats.

作者信息

Saligaut C, Moore N, Daoust M, Chretien P, Boismare F

出版信息

Aviat Space Environ Med. 1982 Jan;53(1):35-9.

Abstract

The action of the dopaminergic agonist, piribedil, on a conditioned avoidance response was studied in normoxic or hypobaric hypoxic rats. This agonist has no effects in normoxia, but induced an anti-hypoxic protection (improvement of learning in hypoxia), antagonised by low doses of pimozide. The mechanism of the anti-hypoxic property seems to be mediated by the stimulation of the postsynaptic dopaminergic receptors, but does not exclude the role of noradrenergic pathways, as shown by the stabilisation of norepinephrine levels during hypoxia after treatment with piribedil.

摘要

在常氧或低压低氧大鼠中研究了多巴胺能激动剂吡贝地尔对条件性回避反应的作用。该激动剂在常氧条件下无作用，但可诱导抗低氧保护作用（改善低氧状态下的学习能力），低剂量匹莫齐特可拮抗此作用。抗低氧特性的机制似乎是由突触后多巴胺能受体的刺激介导的，但并不排除去甲肾上腺素能途径的作用，吡贝地尔治疗后低氧期间去甲肾上腺素水平的稳定就表明了这一点。