常氧或低氧大鼠中的多巴胺能激动剂与条件性回避反应
Dopaminergic agonists and conditioned avoidance response in normoxic or hypoxic rats.
作者信息
Saligaut C, Moore N, Leclerc J L, Boismare F
出版信息
Aviat Space Environ Med. 1981 Jan;52(1):19-23.
The actions of four dopaminergic agonists (apomorphine, bromocriptine, amantadine, piribedil) on a conditioned avoidance response were studied in normoxic or hypobaric hypoxic rats. Low doses of agonists have no effects on normoxia, but induce an antihypoxic protection (improvement of learning both in normoxia and hypobaric hypoxia. The possibility of an antihypoxic property induced by dopaminergic post-synaptic receptors stimulation is discussed and seems to be the main receptors stimulation is discussed and seems to be the main phenomenon while action or other non-specific sites seems to be responsible for the high dose-induced impairment of learning and of resistance to hypoxia.
在常氧或低压低氧大鼠中研究了四种多巴胺能激动剂（阿扑吗啡、溴隐亭、金刚烷胺、吡贝地尔）对条件性回避反应的作用。低剂量激动剂在常氧条件下无作用，但可诱导抗低氧保护作用（改善常氧和低压低氧条件下的学习能力）。文中讨论了多巴胺能突触后受体刺激诱导抗低氧特性的可能性，这似乎是主要现象，而高剂量诱导的学习能力损害和低氧耐受性下降似乎是由作用于其他非特异性位点所致。
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