Walsh T J, Mendelsohn G
Arch Intern Med. 1981 Aug;141(9):1227-8.
Patients with Cushing's syndrome are susceptible to opportunistic infections. Invasive fungal infections in patients with Cushing's syndrome caused by endogenous glucocorticoid excess rarely are reported, and aspergillosis occurring in this setting, to our knowledge, has not been described. Two patients with Cushing's syndrome and notably elevated levels of circulating cortisol had invasive aspergillosis develop. A patient with endogenous hypercortisolism caused by adrenal cortical carcinoma suffered a subarachnoid hemorrhage from rupture of an Aspergillus mycotic aneurysm. The other patient, who had an adrenocorticotrophic hormone-producing prostatic carcinoma, had pulmonary and disseminated aspergillosis develop. Exogenous corticosteroids are known clinically and experimentally to facilitate disseminated aspergillosis. Endogenous hypercortisolism also may bae an important factor predisposing to invasive aspergillosis.
库欣综合征患者易发生机会性感染。由内源性糖皮质激素过多引起的库欣综合征患者发生侵袭性真菌感染的报道很少，据我们所知，在这种情况下发生的曲霉病尚未见描述。两名库欣综合征患者且循环皮质醇水平显著升高，发生了侵袭性曲霉病。一名由肾上腺皮质癌引起内源性皮质醇增多症的患者因曲霉霉菌性动脉瘤破裂导致蛛网膜下腔出血。另一名患有分泌促肾上腺皮质激素的前列腺癌的患者发生了肺部和播散性曲霉病。临床和实验已知外源性皮质类固醇会促进播散性曲霉病。内源性皮质醇增多症也可能是易发生侵袭性曲霉病的一个重要因素。
