el-Sewedy S M, Arafa A, Abdel-Aal G, Mostafa M H
Trans R Soc Trop Med Hyg. 1978;72(5):525-8. doi: 10.1016/0035-9203(78)90176-1.
The activities of serum and urinary alpha-esterases were studied in 49 bilharzial bladder cancer patients, 92 bilharzial patients with other, different, urologic diseases and 22 normal healthy controls. Among the group studied, the bilharzial bladder cancer patients showed the highest level of urinary-alpha-esterases and the lowest ratio of serum/urine activity. These patients showed a significant increase in the activity of urinary alpha-esterases as compared with the normal controls or with the other different bilharzial groups. Although a small but significant increase in serum activity was observed in all the bilharzial groups studied compared with the normal healthy controls, no significant difference was found between the bilharzial bladder cancer patients and the other different bilharzial groups. Biochemical determination of urinary alpha-esterases for bilharzial patients revealed a high degree of accuracy for the diagnosis of bilharzial bladder cancer (95.9%), with low falsely positive (3.26%) and falsely negative (4.08%) results. The activity of urinary alpha-esterases in recommended as a screening test for bilharzial bladder cancer.
对49例血吸虫性膀胱癌患者、92例患有其他不同泌尿系统疾病的血吸虫病患者以及22名正常健康对照者的血清和尿液α-酯酶活性进行了研究。在所研究的组中，血吸虫性膀胱癌患者的尿液α-酯酶水平最高，血清/尿液活性比值最低。与正常对照或其他不同的血吸虫病组相比，这些患者的尿液α-酯酶活性显著增加。尽管与正常健康对照相比，在所研究的所有血吸虫病组中均观察到血清活性有小幅但显著的增加，但血吸虫性膀胱癌患者与其他不同的血吸虫病组之间未发现显著差异。对血吸虫病患者尿液α-酯酶的生化测定显示，对血吸虫性膀胱癌的诊断具有高度准确性（95.9%），假阳性（3.26%）和假阴性（4.08%）结果较低。建议将尿液α-酯酶活性作为血吸虫性膀胱癌的筛查试验。
