El-Sewedy S M, Arafa A M, Mostafa M H, El-Zoghby S M
Cancer Detect Prev. 1981;4(1-4):455-9.
The urinary activities of alpha-naphthyl acetate esterases were measured for groups of bilharzial and nonbilharzial patients with benign urologic diseases and for others with bladder cancer. All these patients showed elevation in the urinary enzyme activity over that given by healthy controls. Bilharzial and nonbilharzial bladder cancer patients exhibited significant increase in urinary enzyme activity as compared with corresponding groups with benign urologic diseases A level of 50 units of enzyme activity was taken as a limit to discriminate between bladder cancer patients and those patients with benign urologic diseases. The specificity and sensitivity of this urinary test exceeded 90% with low falsely positive and negative results. The data of the present study recommended the use of urinary alpha-naphthyl acetate esterases activity as a preliminary screening test for bilharzial and nonbilharzial bladder cancer patients.
对患有良性泌尿系统疾病的血吸虫病患者组和非血吸虫病患者组以及膀胱癌患者进行了尿中醋酸α-萘酯酶活性的检测。所有这些患者的尿酶活性均高于健康对照组。与患有良性泌尿系统疾病的相应组相比，血吸虫病和非血吸虫病膀胱癌患者的尿酶活性显著增加。以50单位酶活性水平作为区分膀胱癌患者和良性泌尿系统疾病患者的界限。该尿液检测的特异性和敏感性超过90%，假阳性和假阴性结果较低。本研究数据建议将尿中醋酸α-萘酯酶活性用作血吸虫病和非血吸虫病膀胱癌患者的初步筛查试验。
