Inwood M J, Barr J D, Warren B A, Chauvin W J
Transfusion. 1978 Nov-Dec;18(6):722-7. doi: 10.1046/j.1537-2995.1978.18679077955.x.
A recent survey indicated that many Canadian hemophiliacs and physicians did not consider it necessary to filter cryoprecipitate prior to infusion. Experiments were performed to demonstrate that no loss of factor activity resulted from filtration of cryoprecipitate through standard blood filters. Furthermore, examination of the material retained on standard and ultrafiltration elements using scanning and transmission electron microscopy demonstrated the presence of amorphous and fibrillar proteins that proved to be largely composed of fibrin. This was accompanied by cellular material including intact and disintegrating leukocytes, erythrocytes, and platelets. Nonbiologic material was also discovered, including cellulose and plastic debris. This study emphasizes the need for effective filtration of cryoprecipitate.
最近的一项调查表明，许多加拿大血友病患者和医生认为在输注前过滤冷沉淀没有必要。进行了实验以证明通过标准血液过滤器过滤冷沉淀不会导致因子活性丧失。此外，使用扫描电子显微镜和透射电子显微镜对保留在标准滤芯和超滤滤芯上的物质进行检查，发现存在无定形和纤维状蛋白质，事实证明这些蛋白质主要由纤维蛋白组成。同时还伴有细胞物质，包括完整的和正在解体的白细胞、红细胞和血小板。还发现了非生物物质，包括纤维素和塑料碎片。这项研究强调了对冷沉淀进行有效过滤的必要性。
