Merritt T A, Curbelo V, Gluck L, Clements R S
Biol Neonate. 1981;39(5-6):217-24. doi: 10.1159/000241440.
Prior to conception, female rabbits were made hyperglycemic by streptozotocin administration. Fetal hyperglycemia and hyperinsulinemia were documented. Although plasma myoinositol concentration were higher in the fetuses of diabetic mothers, the ratio of lung to plasma myoinositol concentrations in 29-day fetal rabbits were lower than control values. CDP-diglyceride:inositol phosphatidyltransferase was reduced by 70% in the diabetic fetuses and their lung tissue phosphatidylinositol content was decreased.
受孕前，通过给予链脲佐菌素使雌性兔子血糖升高。记录到胎儿出现高血糖和高胰岛素血症。尽管糖尿病母亲的胎儿血浆肌醇浓度较高，但29日龄胎儿兔子的肺与血浆肌醇浓度之比低于对照值。糖尿病胎儿的CDP - 甘油二酯：肌醇磷脂酰转移酶降低了70%，且其肺组织磷脂酰肌醇含量减少。
