Stability of neutrophil-releasing activity of plasma obtained from leukapheresed rats and stored at 4 C.

When granulocyte-donor rats were treated prior to pheresis with plasma obtained from previously leukapheresed rats (PPP), granulocytosis and a significant increase in granulocyte yield were observed. Previous studies have demonstrated that such plasma stored at -150 C for up to two weeks preserved the neutrophil-releasing activity. This study demonstrates that neutrophil-releasing activity was satisfactorily preserved when plasma from previously leukapheresed rats was stored at 4 C for three weeks.