Mitchell S C, Waring R H
Biol Neonate. 1981;39(5-6):285-9. doi: 10.1159/000241449.
The in vivo metabolism of promazine and phenothiazine was studied in neonatal guinea pigs aged 1-21 days. Urinary metabolites were estimated for both compounds; marked fluctuations with age were noted, some values being greater than those found for adult animals. Unconjugated phenol (C-oxidation products) levels were very low, although glucuronide excretion was always present; glucuronyl transferase activity did not appear to be limiting, and was present as early as 1 day after birth. Peak sulphoxide excretion showed no correlation with output of other metabolites, suggesting that S- and C-oxidation are not directly linked.
在1至21日龄的新生豚鼠体内研究了丙嗪和吩噻嗪的代谢。对这两种化合物的尿液代谢物进行了评估；发现其随年龄有显著波动，一些值高于成年动物的相应值。尽管总是存在葡萄糖醛酸排泄，但未结合的酚（C-氧化产物）水平非常低；葡萄糖醛酸转移酶活性似乎不是限制因素，在出生后1天就已存在。亚砜排泄峰值与其他代谢物的排出量没有相关性，这表明S-氧化和C-氧化没有直接联系。
