心脏组织中单向阻滞的机制。
Mechanisms of unidirectional block in cardiac tissues.
作者信息
Joyner R W
出版信息
Biophys J. 1981 Jul;35(1):113-25. doi: 10.1016/S0006-3495(81)84778-9.
Abstract
We used numerical solutions for cable equations representing nonuniform cardiac strands to investigate possible mechanisms of unidirectional block (UB) of action potential propagation. Because the presence of UB implies spatial asymmetry in some property along the strand, we varied membrane properties (gNa or leakage conductance), cell diameter, or intercellular resistance as functions of distance such that a propagating action potential encountered the parameter changes either gradually or abruptly. For changes in membrane properties there was very little difference in the effects on propagation for the gradual or abrupt encounter; but, for changes in cell diameter or in intercellular resistance, there were large differences leading to the production of UB over a wide range of parameter values.
摘要
我们使用代表非均匀心肌束的电缆方程的数值解来研究动作电位传播的单向阻滞（UB）的可能机制。由于UB的存在意味着沿束在某些特性上存在空间不对称性，我们将膜特性（钠电导或漏电导）、细胞直径或细胞间电阻作为距离的函数进行变化，以使传播的动作电位逐渐或突然遇到参数变化。对于膜特性的变化，逐渐或突然遇到时对传播的影响差异很小；但是，对于细胞直径或细胞间电阻的变化，差异很大，导致在很宽的参数值范围内产生UB。
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