Vogralik M V, Kurochkin I V
Biull Eksp Biol Med. 1981 Apr;91(4):419-21.
The time-course of changes in the antidiuretic activity of plasma in response to burn injury has been assayed in intact rabbits and in those with an altered body reactivity induced by a preliminary injury to the anterior and posterior hypothalamus. It was demonstrated that in control animals and in rabbits with an injury to the anterior hypothalamus, the burn led to a phasic activation of the hypothalamo-neurohypophyseal system. In animals with an injury to the posterior hypothalamus, the burn, in contrast, inhibited the activation of the system, while the phasic pattern of the responses remained unchanged. The experiments on rats have shown that the decreased activity of the hypothalamo-neurohypophyseal system induced by the pharmacological blockade of the supraoptic nuclei of the hypothalamus raised the body resistance in burn injury.
在完整的兔子以及那些因下丘脑前部和后部预先损伤而导致身体反应性改变的兔子中，测定了血浆抗利尿活性对烧伤损伤的时间进程变化。结果表明，在对照动物和下丘脑前部受损的兔子中，烧伤导致下丘脑 - 神经垂体系统的阶段性激活。相比之下，在下丘脑后部受损的动物中，烧伤抑制了该系统的激活，而反应的阶段性模式保持不变。对大鼠的实验表明，通过药理学方法阻断下丘脑视上核所诱导的下丘脑 - 神经垂体系统活性降低，提高了动物在烧伤损伤中的身体抵抗力。
