Morelli M, Imperato A, Porceddu M L, Di Chiara G
Brain Res. 1981 Jun 29;215(1-2):337-41. doi: 10.1016/0006-8993(81)90513-8.
Kainate or electrolytic lesions were placed unilaterally in the dorsal mesencephalic reticular formation (MRF) or in the deep layers of the superior colliculus (DLSC) on the same side of a unilateral lesion of the medial forebrain bundle with 6-OHDA. Before the lesions the rats turned contralaterally when challenged with 0.25 mg/kg of apomorphine. After lesions of the MRF most rats turned ipsilaterally in response to the same dose of apomorphine. After lesions of the DLSC apomorphine-induced contralateral turning was significantly reduced but not abolished. The results indicate that the MRF and DLSC play a primary role in the expression of turning originated from the striatum.
在单侧内侧前脑束用6-羟基多巴胺（6-OHDA）损伤的同一侧，将红藻氨酸或电损伤单侧置于背侧中脑网状结构（MRF）或上丘深层（DLSC）。在损伤前，用0.25mg/kg阿扑吗啡刺激时，大鼠向对侧转动。MRF损伤后，大多数大鼠对相同剂量的阿扑吗啡产生同侧转动。DLSC损伤后，阿扑吗啡诱导的对侧转动明显减少但未消除。结果表明，MRF和DLSC在源自纹状体的转动表达中起主要作用。
