Rea M A, Simon J R
Brain Res. 1981 Aug 31;219(2):317-26. doi: 10.1016/0006-8993(81)90294-8.
The topographical distribution of choline acetyltransferase, muscarinic receptor binding and high affinity choline uptake was studied in 21 separate areas of the rat striatum. The areas of the nucleus chosen represented dorsolateral, dorsomedial, ventrolateral and ventromedial regions along the rostrocaudal aspect of the striatum, such that a three-dimensional distribution of the cholinergic parameters could be obtained. Within any given rostrocaudal section, no significant dorsoventral differences were noted for any of the cholinergic parameters. On the other hand, marked differences were found in a comparison of the medial and lateral striatum. Choline acetyltransferase, muscarinic receptor binding and high affinity choline uptake were more concentrated in the lateral striatum than the medial striatum, and the magnitude of this medio-lateral disparity increased from rostral to caudal regions of the nucleus. The lateral striatum exhibited no significant rostrocaudal variations in the cholinergic parameters; however, the medial portion of the striatum did exhibit differences along its rostrocaudal extent, with the rostral-most sections being enriched relative to the more caudal sections. These results suggest that the cholinergic system in the striatum is heterogeneously distributed within this nucleus, with the lateral portion possessing a greater cholinergic innervation than the medial portion. They further suggest that future neurochemical studies of cholinergic alterations in the striatum should include a consideration of the possibility of regional effects within the nucleus rather than treating the striatum as a homogeneous tissue.
在大鼠纹状体的21个不同区域研究了胆碱乙酰转移酶、毒蕈碱受体结合和高亲和力胆碱摄取的地形分布。所选择的核区域代表沿着纹状体前后方向的背外侧、背内侧、腹外侧和腹内侧区域，从而可以获得胆碱能参数的三维分布。在任何给定的前后切片内，任何胆碱能参数均未观察到明显的背腹差异。另一方面，在比较内侧和外侧纹状体时发现了显著差异。胆碱乙酰转移酶、毒蕈碱受体结合和高亲和力胆碱摄取在外侧纹状体中比在内侧纹状体中更集中，并且这种内外侧差异的程度从核的前部到后部区域增加。外侧纹状体在胆碱能参数上没有明显的前后变化；然而，纹状体的内侧部分在其前后范围内确实表现出差异，最前部的切片相对于更靠后的切片富含胆碱能。这些结果表明，纹状体内的胆碱能系统在该核内分布不均一，外侧部分比内侧部分具有更大的胆碱能神经支配。它们进一步表明，未来对纹状体胆碱能改变的神经化学研究应考虑核内区域效应的可能性，而不是将纹状体视为均质组织。
