Jeftinija S, Semba K, Randić M
Brain Res. 1981 Aug 31;219(2):456-63. doi: 10.1016/0006-8993(81)90310-3.
An excitability testing procedure of single afferent C-fibers was used to study possible presynaptic actions of norepinephrine (NE) applied to locally at the intraspinal sites of minimal threshold for their antidromic activation in spinalized cats. NE, applied by iontophoresis and/or pressure microinjection, produced dose-related increases in threshold for antidromic activation in 44 of 65 C-fibers. It was concluded that in addition to previously shown postsynaptic depressant action, NE reduces excitability of intraspinal cutaneous C-fibers.
采用单根传入C纤维兴奋性测试程序，研究了在脊髓麻醉猫中，去甲肾上腺素（NE）在其逆向激活最低阈值的脊髓内局部位点的可能突触前作用。通过离子电泳和/或压力微注射施加的NE，在65根C纤维中的44根中，使逆向激活阈值产生剂量相关的增加。得出的结论是，除了先前显示的突触后抑制作用外，NE还降低了脊髓内皮肤C纤维的兴奋性。
