Coupal P, Morin P, Paiement B
Can Anaesth Soc J. 1981 Jul;28(4):350-5. doi: 10.1007/BF03007802.
The recent literature still reports a high incidence of delirium in patients operated with extracorporeal circulation. This syndrome is found more often in patients over 50 years and in patients with a previous history of delirium, alcoholism, drug addiction or cerebral damage and is more frequent after valvular than after coronary surgery. It is also often observed in patients who present major post-operative complications. Attention and concentration capacity are characteristically modified (diminished most of the time) with or without faulty perception (hallucinations), sleep alterations, incoherent language, apathy or agitation. Disorientation and memory troubles are common. Delirium appears within a few hours or a few days of the surgery, its evolution is fluctuant and generally benign. A retrospective study at the Montreal Heart Institute showed an incidence of 2.98 per cent (84 cases/2811 open heart surgery cases) over the last four years. The mean age of these patients was 57.5 years (versus 50.4 for patients without delirium). Major post-operative complications were found in 37 (44 per cent) of these 84 patients. The incidence was lower (1.45 per cent) in coronary than in valvular (4.6 per cent) surgery cases. Several explanations are presented to explain this low incidence.
近期文献仍报道,接受体外循环手术的患者谵妄发生率较高。该综合征在50岁以上患者以及既往有谵妄、酗酒、药物成瘾或脑损伤病史的患者中更为常见,在瓣膜手术后比冠状动脉手术后更频繁出现。在出现重大术后并发症的患者中也经常观察到。注意力和集中能力通常会发生改变(大多数情况下会减弱),伴有或不伴有感知障碍(幻觉)、睡眠改变、语言不连贯、冷漠或躁动。定向障碍和记忆障碍很常见。谵妄在手术后数小时或数天内出现,其进展波动且通常为良性。蒙特利尔心脏研究所的一项回顾性研究显示,在过去四年中,发生率为2.98%(84例/2811例心脏直视手术病例)。这些患者的平均年龄为57.5岁(无谵妄患者为50.4岁)。这84例患者中有37例(44%)出现了重大术后并发症。冠状动脉手术病例的发生率(1.45%)低于瓣膜手术病例(4.6%)。文中提出了几种解释来说明这种低发生率。