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Role of aldehyde dehydrogenase in the metabolism-dependent biological activity of cyclophosphamide.

作者信息

Hipkens J H, Struck R F, Gurtoo H L

出版信息

Cancer Res. 1981 Sep;41(9 Pt 1):3571-83.

PMID:7260916
Abstract
摘要

相似文献

1
Role of aldehyde dehydrogenase in the metabolism-dependent biological activity of cyclophosphamide.醛脱氢酶在环磷酰胺代谢依赖性生物学活性中的作用。
Cancer Res. 1981 Sep;41(9 Pt 1):3571-83.
2
Evidence for an aldehyde possessing alkylating activity as the primary metabolite of cyclophosphamide.有证据表明，一种具有烷基化活性的醛是环磷酰胺的主要代谢产物。
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3
The enzymatic basis of the selective action of cyclophosphamide.环磷酰胺选择性作用的酶学基础。
Cancer Res. 1975 Dec;35(12):3755-61.
4
Metabolism of iphosphamide (2-(2-chloroethylamino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide) and production of a toxic iphosphamide metabolite.
Cancer Res. 1973 May;33(5):1016-22.
5
Aldehyde dehydrogenase-catalyzed bioinactivation of cyclophosphamide.醛脱氢酶催化的环磷酰胺生物失活作用。
Prog Clin Biol Res. 1989;290:49-63.
6
[Immunosuppressant effect of cyclophosphamide activated in vitro by liver microsomes from different strains of mice].[不同品系小鼠肝脏微粒体体外激活环磷酰胺的免疫抑制作用]
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7
Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.
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Metabolism of 5-aminoquinoline with liver cytosol enzyme.5-氨基喹啉与肝细胞溶质酶的代谢
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9
Human and mouse hepatic aldehyde dehydrogenases important in the biotransformation of cyclophosphamide and the retinoids.人和小鼠肝脏醛脱氢酶在环磷酰胺和类视黄醇的生物转化中起重要作用。
Adv Exp Med Biol. 1991;284:97-104. doi: 10.1007/978-1-4684-5901-2_12.
10
Proceedings: Relationship between aldehyde oxidase activity and biological activity of cyclophosphamide.论文集：醛氧化酶活性与环磷酰胺生物活性之间的关系
Jpn J Pharmacol. 1974;24(0):s:81.

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High apoptosis-inducing and antitumor activities of the products of biological but not chemical cyclophosphamide activation.
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Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokinetic study.
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Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide).环磷酰胺、其主要活性代谢物及新型恶唑磷（国际非专利药品名称：马法兰磷酰胺）的体外细胞毒性比较
Invest New Drugs. 1984;2(2):141-8. doi: 10.1007/BF00232343.
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Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.肝微粒体代谢诱导对环磷酰胺毒性的影响。
Br J Cancer. 1985 Jan;51(1):67-75. doi: 10.1038/bjc.1985.10.
7
Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide.
Arch Toxicol. 1987 Dec;61(2):126-30. doi: 10.1007/BF00661370.
8
Cyclophosphamide metabolism in the primary immune organs of the chick: assays of drug activation, P450 expression, and aldehyde dehydrogenase.环磷酰胺在雏鸡主要免疫器官中的代谢：药物活化、细胞色素P450表达及醛脱氢酶的测定
Arch Toxicol. 1991;65(1):32-8. doi: 10.1007/BF01973500.