Brown R R
Cancer Res. 1981 Sep;41(9 Pt 2):3741-2.
A study was done to evaluate the effect of quantity and degree of saturation of dietary fat on the incidence of spontaneous tumors in male and female Swiss mice and in female C3H mice and on the incidence of tumors induced by s.c. administration of 1,2-dimethylhydrazine (DMH) in Swiss mice. Diets contained 5 or 17% fat substituted isocalorically for sucrose in a semipurified diet. Gross autopsy results suggest that the quantity of dietary fat, when fed isocalorically, did not appreciably influence the incidence of spontaneous or DMH-induced tumors in these mouse strains. Mice fed 17% of the triene fat generally had a higher incidence of liver tumors than corresponding groups fed the saturated fat. High levels (0.5%) of butylated hydroxyanisole protected female C3H mice from spontaneous liver tumors, but low levels of butylated hydroxyanisole (200 ppm of fat) did not protect. Neither level of butylated hydroxyanisole influenced tumor incidence in CD-1 mice. The absence of gross bowel tumors in animals given DMH was unexpected but may be related to the levels of cholesterol and fiber in the diets, since these factors are reported to influence the effects of DMH.
开展了一项研究，以评估膳食脂肪的量和饱和度对雄性和雌性瑞士小鼠以及雌性C3H小鼠自发性肿瘤发病率的影响，以及对皮下注射1,2 - 二甲基肼（DMH）诱导的瑞士小鼠肿瘤发病率的影响。在半纯化饮食中，用5%或17%的脂肪等量替代蔗糖。大体尸检结果表明，当等量喂食时，膳食脂肪的量并未明显影响这些小鼠品系中自发性或DMH诱导的肿瘤发病率。喂食17%三烯脂肪的小鼠肝脏肿瘤发病率通常高于喂食饱和脂肪的相应组。高剂量（0.5%）的丁基羟基茴香醚可保护雌性C3H小鼠免受自发性肝脏肿瘤的侵害，但低剂量的丁基羟基茴香醚（脂肪中200 ppm）则无保护作用。两种剂量的丁基羟基茴香醚均未影响CD - 1小鼠的肿瘤发病率。给予DMH的动物未出现大体肠道肿瘤这一情况出乎意料，但可能与饮食中的胆固醇和纤维水平有关，因为据报道这些因素会影响DMH的作用。
