Zevenbergen J L, Verschuren P M, Zaalberg J, van Stratum P, Vles R O
Unilever Research Laboratorium Vlaardingen, The Netherlands.
Nutr Cancer. 1992;17(1):9-18. doi: 10.1080/01635589209514168.
The relationship between dietary fat consumption and the incidence of breast cancer, if any, needs to be quantified so that dietary guidelines can be issued for the prevention of breast cancer. Frequently, only two widely different dietary fat levels, often differing in essential fatty acid content, have been compared in animal models. Moreover, the latent period in common animal models for breast cancer is very short and does not reflect the relatively long latent periods in human breast cancer. We describe a study with BALB/c-MTV mice, a strain with a high average tumor incidence and a latent period of over 60 weeks on average. The mice were fed diets with fat levels ranging from 10% to 40% of energy, in which fat was isocalorically substituted for carbohydrates. The level of linoleic acid in these diets was kept constant at 6.5% of energy. Both the mean tumor incidence and latent periods of the groups fed diets with 10-16% of energy as fat were not significantly different from each other. There were also no differences between these parameters in the groups fed 22-40% of energy as fat. However, the mean incidence and latent period of the groups fed 22% or more of energy as fat was significantly higher than that of the groups fed less fat. We conclude that above about 22% of energy, fat does not influence the incidence and latent period of mammary tumors in BALB/c-MTV mice.
饮食中脂肪摄入量与乳腺癌发病率之间的关系（若存在）需要进行量化，以便能够发布预防乳腺癌的饮食指南。在动物模型中，通常仅比较了两种差异很大的饮食脂肪水平，这两种水平的必需脂肪酸含量往往也不同。此外，常见动物模型中乳腺癌的潜伏期非常短，无法反映人类乳腺癌相对较长的潜伏期。我们描述了一项针对BALB/c-MTV小鼠的研究，该品系平均肿瘤发病率较高，平均潜伏期超过60周。给这些小鼠喂食脂肪含量占能量10%至40%的饮食，其中脂肪以等热量的方式替代碳水化合物。这些饮食中亚油酸的水平保持在能量的6.5%不变。喂食脂肪含量占能量10%至16%的饮食组的平均肿瘤发病率和潜伏期彼此之间没有显著差异。喂食脂肪含量占能量22%至40%的饮食组在这些参数上也没有差异。然而，喂食脂肪含量占能量22%或更多的饮食组的平均发病率和潜伏期显著高于喂食较少脂肪的组。我们得出结论，当能量中脂肪含量高于约22%时，脂肪不会影响BALB/c-MTV小鼠乳腺肿瘤的发病率和潜伏期。
